2. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor NF-κB Epigenetics TGF-beta/Smad
  3. FABP Cannabinoid Receptor PPAR NF-κB PKC
  4. ART26.12

ART26.12 is a potent, selective and orally active inhibitor of FABP5. ART26.12 can regulate lipid metabolism and activate cannabinoid receptors. ART26.12 has analgesic effects and can be used in the research of diseases such as peripheral neuropathy and psoriasis.

For research use only. We do not sell to patients.

ART26.12 Chemical Structure

ART26.12 Chemical Structure

CAS No. : 2766800-24-0

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ART26.12 Related Antibodies

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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Description

ART26.12 is a potent, selective and orally active inhibitor of FABP5. ART26.12 can regulate lipid metabolism and activate cannabinoid receptors. ART26.12 has analgesic effects and can be used in the research of diseases such as peripheral neuropathy and psoriasis[1][2].

In Vitro

ART26.12 (1-10 μM; 24 h) reduces the levels of cytokines, chemokines, and markers of keratinocyte proliferation or differentiation, and increases the levels of certain antimicrobial peptides in the reconstructed human epidermis stimulated by cytokines (IL-17, IL-22, and TNF)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ART26.12 Related Antibodies
In Vivo

ART26.12 (25-100 mg/kg; oral administration; twice daily; 10 days) exerts ameliorative effects in Imiquimod (HY-B0180)-induced psoriatic mouse models[1].
ART26.12 (25-100 mg/kg; oral administration; single dose) exhibits ameliorative and analgesic effects in Oxaliplatin (HY-17371)-induced peripheral neuropathy models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice treated Imiquimod (HY-B0180)[1]
Dosage: 25 and 100 mg/kg
Administration: Oral administration; twice daily; 10 days
Result: Reduced the total Psoriasis Area and Severity Index (PASI) score from day 7 and improved skin thickness and scaling symptoms.
Decreased the severity of symptoms such as hyperkeratosis, parakeratosis, epidermal acanthosis, and inflammatory infiltration.
Rescued the expression of FLG-2 and promoted the expression of proteins related to the epidermal differentiation complex, and regulated PPAR, NF-κB, and PKC pathways.
Widely regulated lipids, including ceramides and linoleic acid derivatives.
Animal Model: Male Sprague Dawley rats (150-210 g) treated Oxaliplatin (HY-17371)[2]
Dosage: 25, 50, 75, and 100 mg/kg
Administration: Oral administration; single dose
Result: Significantly increased the paw withdrawal threshold (PWT) for mechanical allodynia at 30 minutes to 8 hours post-dose, with the effect dependent on CB1 receptor and potentially involving CB2, TRPV1, and PPARα antagonists.
Molecular Weight

472.53

Formula

C29H28O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1[C@H](C2=C(C=CC=C2)OC)[C@@H]([C@H]1C3=C(C=CC=C3)OC)C(O)=O)OC4CC5=CC=CC=C5C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (264.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1163 mL 10.5813 mL 21.1627 mL
5 mM 0.4233 mL 2.1163 mL 4.2325 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1163 mL 10.5813 mL 21.1627 mL 52.9067 mL
5 mM 0.4233 mL 2.1163 mL 4.2325 mL 10.5813 mL
10 mM 0.2116 mL 1.0581 mL 2.1163 mL 5.2907 mL
15 mM 0.1411 mL 0.7054 mL 1.4108 mL 3.5271 mL
20 mM 0.1058 mL 0.5291 mL 1.0581 mL 2.6453 mL
25 mM 0.0847 mL 0.4233 mL 0.8465 mL 2.1163 mL
30 mM 0.0705 mL 0.3527 mL 0.7054 mL 1.7636 mL
40 mM 0.0529 mL 0.2645 mL 0.5291 mL 1.3227 mL
50 mM 0.0423 mL 0.2116 mL 0.4233 mL 1.0581 mL
60 mM 0.0353 mL 0.1764 mL 0.3527 mL 0.8818 mL
80 mM 0.0265 mL 0.1323 mL 0.2645 mL 0.6613 mL
100 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.5291 mL
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ART26.12 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ART26.122766800-24-0FABPCannabinoid ReceptorPPARNF-κBPKCFatty acid-binding proteinPeroxisome proliferator-activated receptorsNuclear factor-κBNuclear factor-kappaBProtein kinase Cpsoriatic modelperipheral neuropathy modelhuman epidermisInhibitorinhibitorinhibit

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