Antituberculosis agent-16 

Antituberculosis agent-16 is an orally active antituberculosis agent. Antituberculosis agent-16 exhibits stable antituberculosis activity with a MIC of 0.48 μg/mL against Mycobacterium tuberculosis H37Rv sensitive strain and 0.49 μg/mL against multidrug-resistant strain 14862. Antituberculosis agent-16 shows high Caco-2 permeability. Antituberculosis agent-16 can be used for the research of infection^[1].

Antituberculosis agent-16 shows low cytotoxicity to Vero cells with an IC₅₀ of 37.14 μg/mL^[1].
Antituberculosis agent-16 has high cell membrane permeability with an apparent permeability coefficient (Papp) of 46.1×10^-6 cm/s in Caco-2 assay^[1].
Antituberculosis agent-16 (1-10 μg/mL, 72 h) dose-dependently reduces the intracellular Mycobacterium tuberculosis load in mouse J774A.1 macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

395.49

C₂₃H₂₉N₃O₃

O=C(C1=CC(C2=CC(OCCOC)=NC=C2)=CN1)N[C@H]3C4CC5C[C@@H](C4)C[C@H]3C5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wu Y, et al. Optimization of pyrrole-2-carboxamide to develop a potent antituberculosis agent with improved physicochemical property and druggability. Bioorg Chem. 2025 Oct;165:109016.