beta Arrestin 1 Antibody (YA5236)

beta Arrestin 1 Antibody (YA5236) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to beta Arrestin 1.

β-Arrestin 1 is a multifunctional regulatory protein primarily involved in modulating G-protein coupled receptor (GPCR) signaling, including receptor desensitization and resensitization. It binds to GPRK-phosphorylated receptors, sterically hindering their coupling to cognate G-proteins, thereby mediating homologous desensitization. As an endocytic adapter (CLASP), β-Arrestin 1 recruits GPCRs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs), facilitating receptor internalization. The extent of its involvement varies significantly depending on the receptor, agonist, and cell type. Class A receptors (e.g., ADRB2, OPRM1) dissociate from β-Arrestin 1 near the plasma membrane and undergo rapid recycling, while Class B receptors (e.g., AVPR2, AGTR1) internalize as complexes with β-Arrestin 1 and traffic to endosomal vesicles for prolonged periods. Additionally, β-Arrestin 1 acts as a signaling scaffold, activating pathways such as MAPK (e.g., ERK1/2), AKT1, and p38 MAPK, and participates in cytoskeletal rearrangement, chemotaxis, and transcriptional regulation. It also interacts with proteins like TRAF6 and ITCH to modulate Toll-like receptor, IL-1 receptor, and NOTCH signaling. by similar: Binds inositolhexakisphosphate (InsP6).

P49407

Observed band size: 50 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Mouse, Rat, Human

WB: 1:500

WB

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human beta Arrestin 1 protein fragments expressed in E.coli.