WDR5 Antibody (YA5099)

WDR5 Antibody (YA5099) is a mouse-derived and non-conjugated monoclonal antibody, targeting to WDR5. It can be applicated for WB, ELISA assays, in the background of human.

WDR5 is a protein involved in histone modification, contributing to the positioning of the N-terminus of histone H3 for efficient trimethylation at Lys-4 (PubMed:16829960). As part of the MLL1/MLL complex, it participates in methylation and dimethylation of histone H3 at Lys-4 (PubMed:19556245), with H3 Lys-4 methylation serving as a specific tag for epigenetic transcriptional activation (PubMed:18840606). Within the NSL complex, it may be involved in the acetylation of nucleosomal histone H4 at multiple lysine residues (PubMed:19103755, PubMed:20018852). By similarity, it may regulate osteoblast differentiation. Additionally, in association with RBBP5 and ASH2L, WDR5 stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A, and SETD1B (PubMed:21220120, PubMed:22266653).

P61964

Predicted band size: 37 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human WDR5 expressed in E. Coli.