TrkA+B+C Antibody (YA027)

Cat. No.: HY-P80359: Data Sheet COA
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TrkA+B+C Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 92 kDa, targeting to TrkA+B+C. It can be used for WB,ICC,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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TrkA+B+C Antibody (YA027) Featured Recommendations:

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

Biological Activity
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Description	TrkA+B+C Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 92 kDa, targeting to TrkA+B+C. It can be used for WB,ICC,IHC-P assays with tag free, in the background of Human, Mouse, Rat.
Background	The TrkA protein, a receptor tyrosine kinase, plays a vital role in the development and maturation of the central and peripheral nervous systems by regulating the proliferation, differentiation, and survival of sympathetic and sensory neurons. Serving as a high-affinity receptor for NGF, its primary ligand, TrkA can also be activated by NTF3/neurotrophin-3, though NTF3 specifically supports axonal extension through NTRK1 without influencing neuron survival. Upon dimeric NGF ligand-binding, TrkA undergoes homodimerization, autophosphorylation, and activation, subsequently recruiting, phosphorylating, and/or activating downstream effectors such as SHC1, FRS2, SH2B1, SH2B2, and PLCG1. These effectors regulate distinct yet overlapping signaling cascades, steering cell survival and differentiation. Through SHC1 and FRS2, TrkA activates a GRB2-Ras-MAPK cascade controlling cell differentiation and survival, while through PLCG1, it modulates NF-Kappa-B activation and the transcription of genes crucial for cell survival. Additionally, through SHC1 and SH2B1, TrkA controls a Ras-PI3 kinase-AKT1 signaling cascade, further contributing to the regulation of cell survival. In the absence of ligand and activation, TrkA may promote cell death, underscoring the dependence of neuron survival on trophic factors.
Tag	Free
Gene ID	4914 [NCBI]
SwissProt ID	P04629
Molecular Weight	Predicted band size: 92 kDa; Observed band size: 130 kDa
Purity	Protein A affinity purified.
Subcellular Location	Membrane, Endosome membrane.
Conjugation	Non-conjugated
Modification	Unmodified
Research Field	Neuroscience
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human, Mouse, Rat
Tested Reactivity	Human, Mouse, Rat
Dilution Ratio	WB: 1:1,000-1:5,000 ;ICC: 1:50-1:200 ;IHC-P: 1:50-1:200
Application	WB, ICC/IF, IHC-P
Tested Applications	WB, IHC-P, ICC/IF
Appearance	Liquid
Formulation	Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	Synthetic peptide corresponding to Human TrkB.AA range:773-822.
Database	Entrez Gene: 4914 Human ; 4915 Human ; 4916 Human ; 18211 Mouse ; 18212 Mouse ; 18213 Mouse ; 25054 Rat 29613 SwissProt: P04629 Human ; Q16288 Human ; Q16620 Human ; P15209 Mouse ; Q3UFB7 Mouse ; Q6VNS1 Mouse ; P35739 Rat Q03351 OMIM: 256800 Human
Documentation	Select Batch: Data Sheet (235 KB) SDS (251 KB) COA (206 KB) User Guide for Antibodies (1077 KB)

TrkA+B+C Antibody (YA027) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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TrkA+B+C Antibody (YA027)

TrkA+B+C Antibody (YA027) Featured Recommendations:

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