BAFF Antibody (YA4582)

BAFF Antibody (YA4582) is a mouse-derived and non-conjugated IgG1 antibody, targeting to TNFSF13B. It can be applicated for WB, ICC/IF, FC, ELISA assays, in the background of human.

BAFF is a cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL also binds to these two receptors. Together, they form a 2 ligands - 2 receptors pathway involved in stimulating B- and T-cell function and regulating humoral immunity. Additionally, BAFF promotes the survival of mature B-cells and B-cell responses through a third B-cell-specific receptor, BAFFR/BR3. Isoform 2 appears to inhibit the secretion and bioactivity of isoform 1. In autoimmune and proliferative B-cell diseases, BAFF acts as a transcription factor for its own parent gene in association with the NF-kappa-B p50 subunit. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of numerous genes involved in innate immune responses and apoptosis regulation. by similar: TNFSF13/APRIL also binds to the same two receptors.

Q9Y275

Predicted band size: 31 kDa; Observed band size: 31 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

WB: 1/500-1/2000; IF: 1/100-1/500; FC: 1/200-1/400; ELISA: 1/10000

WB, ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human TNFSF13B (AA: 116-278) expressed in E. Coli.