TIP60 Antibody (YA5082)

TIP60 Antibody (YA5082) is a mouse-derived and non-conjugated monoclonal antibody, targeting to TIP60. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

TIP60 is the catalytic subunit of the NuA4 histone acetyltransferase complex, which activates transcription of select genes primarily by acetylating nucleosomal histones H2A and H4. The NuA4 complex is involved in transcriptional programs linked to proto-oncogene-mediated growth induction, tumor suppressor-mediated growth arrest, replicative senescence, apoptosis, and DNA repair. In DNA double-strand break (DSB) repair, it promotes homologous recombination (HR) by inhibiting TP53BP1 chromatin binding and catalyzing H2AX acetylation to recruit NBN/NBS1 to damage sites. TIP60 also acetylates non-histone proteins like ATM, TP53/p53, and others, participating in nucleotide excision repair (NER), autophagy regulation, lipid metabolism, and antiviral responses. It can utilize different acyl-CoA substrates (e.g., crotonyl-CoA, lactyl-CoA) to mediate protein crotonylation, lactylation, and other modifications. During microbial infection, TIP60 acetylates flavivirus NS3 protein to facilitate viral replication. by similar: The NuA4 complex plays a vital role in hematopoietic stem cell maintenance by preserving acetylated H2A.Z/H2AZ1 at MYC target genes; promotes histone hyperacetylation during spermatid development; and enhances transcriptional elongation in the circadian cycle via BMAL1 acetylation.

Q92993

Predicted band size: 59 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; IHC: 1:200-1:1000; ELISA: 1:10000; ICC/IF: 1:50-200

WB, IHC-P, ICC/IF, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human TIP60 expressed in E. Coli.