TIMD4 Antibody (YA4427)

TIMD4 Antibody (YA4427) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TIMD4.

TIMD4 is a phosphatidylserine receptor that plays diverse roles in immune responses, including phagocytosis of apoptotic cells and T-cell regulation. It controls T-cell activation in a bimodal fashion: suppressing the activation of naive T-cells by inducing cell cycle arrest, while enhancing the proliferation of activated T-cells through AKT1 and ERK1/2 phosphorylation and downstream signaling pathways (by similar). Additionally, TIMD4 is involved in efferocytosis, the process by which phagocytic cells remove apoptotic cells. Mechanistically, it facilitates the engulfment of apoptotic cells or exogenous particles by anchoring them to phagocytes via direct binding to phosphatidylserine on apoptotic cells, while other engulfment receptors like MERTK efficiently recognize and mediate their ingestion. TIMD4 also promotes autophagy by suppressing NLRP3 inflammasome activity through activation of the LKB1/PRKAA1 pathway in a phosphatidylserine-dependent manner (by similar). In microbial infection, TIMD4 positively contributes to exosome-mediated trafficking of HIV-1 virus and its entry into immune cells.

Q96H15

Predicted band size: 42 kDa; Observed band size: 70 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IF: 1/50-1/200; FC: 1/200-1/400; ELISA: 1/10000

ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human TIMD4 (AA: extra 25-314) expressed in E. Coli.