TGFBR3 Antibody (YA4173)

TGFBR3 Antibody (YA4173) is a mouse-derived and non-conjugated IgG2b antibody, targeting to TGFBR3. It can be applicated for WB, ELISA assays, in the background of human, mouse.

TGFBR3 is a cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. It initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with ligands such as TGFB1, BMP2, BMP5, BMP7, or GDF5. Additionally, TGFBR3 acts as a cell surface coreceptor for BMP ligands, enhancing ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking. It promotes epithelial cell adhesion, focal adhesion formation, and integrin signaling during epithelial cell spreading on fibronectin. By interacting with the scaffolding protein beta-arrestin2/ARRB2, TGFBR3 regulates migration or actin cytoskeleton and promotes CDC42 activation while inhibiting NF-kappa-B. In gonadotrope cells, it functions as an inhibin A coreceptor, regulating follicle-stimulating hormone (FSH) levels and female fertility (by similar). TGFBR3 also inhibits directed and random cell migration in epithelial cells by altering actin cytoskeletal organization. Upon binding to BMP2 or TGFB2, it participates in epithelial-mesenchymal transformation (EMT) by activating the PAR6/SMURF1/RHOA pathway (by similar). Furthermore, TGFBR3 may serve as a receptor for human cytomegalovirus in various cell types by interacting with the HCMV trimer composed of GO, GH, and GL.

Q03167

Predicted band size: 93 kDa; Observed band size: 93 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human, Mouse

WB: 1/500-1/2000; ELISA: 1/10000

WB, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2b

Purified recombinant fragment of human TGFBR3 (AA: 147-328 ) expressed in E. Coli.