TGF beta Receptor II Antibody (YA6173)

TGF beta Receptor II Antibody (YA6173) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TGF β Receptor II. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

TGF β Receptor II (TGFBR2) is a transmembrane serine/threonine kinase that forms a non-promiscuous receptor complex with TGF-beta type I receptor (TGFBR1) to specifically bind cytokines TGFB1, TGFB2, and TGFB3. It transduces signals from these cytokines into the cell, regulating diverse physiological and pathological processes such as cell cycle arrest in epithelial/hematopoietic cells, mesenchymal cell proliferation/differentiation, wound healing, extracellular matrix production, immunosuppression, and carcinogenesis. The receptor complex consists of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer, where constitutively active TGFBR2 phosphorylates and activates TGFBR1. Activated TGFBR1 then phosphorylates SMAD2, which dissociates from the receptor, binds SMAD4, and translocates to the nucleus to modulate TGF-beta-responsive gene transcription (canonical SMAD-dependent pathway). TGFBR2 also participates in non-canonical SMAD-independent signaling, exhibits TGF-beta-activated receptor activity, and binds TGFB1/2/3 with picomolar affinity without auxiliary receptors while blocking TGFB1-mediated SMAD2/3 activation.

P37173

Predicted band size: 65 kDa; Observed band size: 65 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC: 1:200-1:500; WB: 1:1000-1:5000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200,

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG