TERT Antibody (YA3504)

TERT Antibody (YA3504) is a mouse-derived and non-conjugated IgG1 antibody, targeting to TERT. It can be applicated for IHC-P, FC, ELISA assays, in the background of human.

TERT is the catalytic subunit of telomerase, a ribonucleoprotein enzyme critical for chromosome end replication in most eukaryotes. It is active in progenitor and cancer cells but exhibits minimal or no activity in normal somatic cells. As the core component of the telomerase holoenzyme complex, TERT elongates telomeres by functioning as a reverse transcriptase that adds TTAGGG repeats to chromosomal termini using an internal RNA template. Its catalytic cycle involves primer binding, extension, and product release upon reaching template boundaries. TERT shows higher activity on substrates containing 2-3 telomeric repeats, with regulation mediated by associated proteins, chaperones, and post-translational modifications. It also modulates Wnt signaling and plays pivotal roles in aging and antiapoptosis processes.

O14746

Predicted band size: 127 kDa; Observed band size: 127 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IHC: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

IHC-P, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human TERT (AA: 1029-1132) expressed in E. Coli.