SSTR2 Antibody (YA3946)

SSTR2 Antibody (YA3946) is a mouse-derived and non-conjugated IgG1 antibody, targeting to SSTR2. It can be applicated for FC, ELISA assays, in the background of human.

The SSTR2 Protein-VLP serves as a receptor for somatostatin-14 and -28, coupling with pertussis toxin-sensitive G proteins to inhibit adenylyl cyclase. Additionally, it stimulates phosphotyrosine phosphatase and PLC through pertussis toxin-insensitive and sensitive G proteins, while inhibiting calcium entry by suppressing voltage-dependent calcium channels. In pancreatic alpha- and beta-cells, SSTR2 acts as the functionally dominant somatostatin receptor, mediating the inhibitory effects of somatostatin-14 on hormone secretion. Beyond its role in pancreatic cells, SSTR2 inhibits cell growth by enhancing MAPK1 and MAPK2 phosphorylation, leading to the up-regulation of CDKN1B. It further contributes to neuronal migration and axon outgrowth, potentially participating in neuron development and maturation during brain development. SSTR2 mediates the negative regulation of insulin receptor signaling through PTPN6 and inactivates SSTR3 receptor function following heterodimerization. Existing as both homodimers and heterodimers with SSTR3 and SSTR5, SSTR2 undergoes agonist-induced dissociation into monomers, a crucial step for receptor internalization. Interactions with beta-arrestin and SHANK1 further modulate receptor internalization and function.

P30874

Predicted band size: 41.3 kDa; Observed band size: 42 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

FC: 1/200-1/400; ELISA: 1/10000

FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human SSTR2 expressed in E. Coli.