SOCS2 Antibody (YA072)

Cat. No.: HY-P80328: Data Sheet User Guide for Antibodies
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SOCS2 Antibody (YA072) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SOCS2.

For research use only. We do not sell to patients.

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10 μL		Ask For Quote & Lead Time
50 μL		Ask For Quote & Lead Time
100 μL		Ask For Quote & Lead Time

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SOCS2 Antibody (YA072) Featured Recommendations:

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

Biological Activity
Technical Parameters
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Documentation

Description	SOCS2 Antibody (YA072) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SOCS2.
Background	SOCS2 is the substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins such as EPOR and GHR. It specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR following its phosphorylation by JAK2. The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR.
Tag	Free
Gene ID	8835 [NCBI]
SwissProt ID	O14508
Molecular Weight	Predicted band size: 22 kDa; Observed band size: 22 kDa
Purity	Protein A affinity purified.
Subcellular Location	Cytosol.
Conjugation	Non-conjugated
Modification	Unmodified
Research Field	Cell Biology
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human
Dilution Ratio	WB: 1:500-1:2,000; ICC: 1:50-1:200; IP: 1:10-1:50; IHC-P: 1:1,000
Application	WB, ICC/IF, IP, IHC-P
Appearance	Liquid
Formulation	Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	Synthetic peptide corresponding to Human SOCS2.AA range:1-198.
Database	Entrez Gene: 8835 Human SwissProt: O14508 Human OMIM: 605117 Human
Documentation	Data Sheet (234 KB) User Guide for Antibodies (1077 KB)

SOCS2 Antibody (YA072) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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SOCS2 Antibody (YA072)

SOCS2 Antibody (YA072) Featured Recommendations:

Biological Activity

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SOCS2 Antibody (YA072) Related Classifications

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