SOCS-3 Antibody (YA5161)

SOCS-3 Antibody (YA5161) is a mouse-derived and non-conjugated monoclonal antibody, targeting to SOCS-3. It can be applicated for WB, IHC-P, ICC/IF assays, in the background of human, pig.

SOCS3, a member of the SOCS family, operates within a classical negative feedback system that intricately regulates cytokine signal transduction. Particularly, SOCS3 exerts its influence on the JAK/STAT pathway, engaging in the negative regulation of cytokines. By binding to tyrosine kinase receptors such as IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF, and leptin receptors, SOCS3 effectively inhibits cytokine signal transduction. Notably, its interaction with JAK2 hampers the kinase activity of the latter, thereby modulating IL6 signaling. Beyond its role in signal transduction, SOCS3 plays a critical part in suppressing fetal liver erythropoiesis and regulating the initiation and sustenance of allergic responses mediated by T-helper type 2 cells. Moreover, it serves as a probable substrate recognition component within a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, facilitating the ubiquitination and subsequent proteasomal degradation of target proteins—an aspect integral to protein modification and ubiquitination processes.

O14543

Predicted band size: 25 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Pig

WB: 1:1000-1:2000; IHC: 1:500-1:1000; ICC/IF: 1:50-200

WB, IHC-P, ICC/IF

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human SOCS-3 (N-terminus) protein fragments expressed in E.coli.