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  5. SMN Antibody (YA2194)

SMN Antibody (YA2194)

Cat. No.: HY-P82449
User Guide for Antibodies Technical Support

SMN Antibody (YA2194) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2194), targeting SMN, with a predicted molecular weight of 32 kDa (observed band size: 36 kDa). SMN Antibody (YA2194) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

SMN Antibody (YA2194) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2194), targeting SMN, with a predicted molecular weight of 32 kDa (observed band size: 36 kDa). SMN Antibody (YA2194) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.
Background

The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, playing a crucial role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, and SNRPG) that assemble into a heptameric protein ring on the Sm site of small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF, and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A, which regulates core snRNP assembly. The SMN complex accepts the trapped 5Sm proteins from CLNS1A to form an intermediate, with SMN1 acting as a structural backbone alongside GEMIN2 to gather Sm complex subunits. Binding of snRNA within 5Sm triggers the eviction of the SMN complex, allowing SNRPD3 and SNRPB to complete core snRNP assembly. The SMN complex also ensures proper splicing of U12 intron-containing genes, which may be important for normal motor and proprioceptive neuron development. Additionally, it resolves RNA-DNA hybrids formed by RNA polymerase II, which create R-loops in transcription termination regions, a critical step in proper transcription termination. It may also play a role in small nucleolar ribonucleoprotein (snoRNPs) metabolism.
Gene ID
SwissProt ID
Synonyms
SMN1; SMN; SMNT; SMN2; SMNC; Survival motor neuron protein; Component of gems 1; Gemin-1
Molecular Weight

Predicted band size: 32 kDa; Observed band size: 36 kDa
Purity

Affinity Chromatography
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Neuroscience
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000;IHC: 1/50-1/100;IP: 1/50
Application

WB, IHC-P, IP
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthesized peptide derived from human SMN1
Database

Entrez Gene: 6606 Human ; 20595 Mouse ; 64301 Rat

SwissProt: Q16637 Human ; P97801 Mouse ; O35876 Rat

OMIM: 253300 Human

Documentation
User Guide for Antibodies (1077 KB)

SMN Antibody (YA2194) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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SMN Antibody (YA2194)
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