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  5. SMARCC1 Antibody (YA1047)

SMARCC1 Antibody (YA1047)

Cat. No.: HY-P81308A
User Guide for Antibodies Technical Support

SMARCC1 Antibody (YA1047) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SMARCC1.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

SMARCC1 Antibody (YA1047) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SMARCC1.
Background

SMARCC1 is involved in transcriptional activation and repression of select genes through chromatin remodeling (alteration of DNA-nucleosome topology). It is a component of SWI/SNF chromatin remodeling complexes, which carry out key enzymatic activities by altering DNA-histone contacts within nucleosomes in an ATP-dependent manner. SMARCC1 may stimulate the ATPase activity of the complex's catalytic subunit. It belongs to the neural progenitor-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a transition occurs from a stem/progenitor chromatin remodeling mechanism to a postmitotic mechanism as neurons exit the cell cycle and mature. This transition involves a switch in subunit composition between npBAF and nBAF complexes: as neural progenitors differentiate into neurons, ACTL6A/BAF53A and PHF10/BAF45A in npBAF complexes are replaced by homologous alternative subunits ACTL6B/BAF53B and either DPF1/BAF45B or DPF3/BAF45C in neuron-specific nBAF complexes. The npBAF complex is essential for the self-renewal and proliferative capacity of multipotent neural stem cells (by similar). The nBAF complex, along with CREST, regulates the activity of genes critical for dendrite growth.
Gene ID
SwissProt ID
Synonyms
BAF155; CRACC1; Rsc8; SMARCC1; SRG3; SWI3
Molecular Weight

Predicted band size: 123 kDa; Observed band size: 155 kDa
Purity

Affinity Chromatography
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Epigenetics and Nuclear Signaling
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Rat
Dilution Ratio

WB: 1:500-1:1000; IF: 1:50-1:200; IP: 1:50; FC: 1:50-1:100
Application

WB, ICC/IF, IP, FC
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthesized peptide derived from human SMARCC1/BAF155
Database

Entrez Gene: 6599 Human ; 20588 Mouse ; 301020 Rat

SwissProt: Q92922 Human ; P97496 Mouse ;

OMIM: 620241 Human

Documentation
User Guide for Antibodies (1077 KB)

SMARCC1 Antibody (YA1047) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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SMARCC1 Antibody (YA1047)
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