SMAD6 Antibody (YA3539)

SMAD6 Antibody (YA3539) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SMAD6.

SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta (TGF-β) receptors within the TGF-β superfamily pathway. It mediates the anti-inflammatory activities of TGF-β and BMP by directly interacting with PEL1 to suppress IL1R-TLR signaling, thereby inhibiting NF-κB activation, nuclear transport, and NF-κB-mediated expression of pro-inflammatory genes. Additionally, SMAD6 blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for binding to receptor-activated SMAD1 and binds to regulatory elements in target promoter regions. by similar: It is also involved in modulating other signaling pathways, such as competing with SMAD4 for binding sites.

O43541

Predicted band size: 53 kDa; Observed band size: 53 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal Antibody

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human SMAD6 aa 238-496.