SHP-1 Antibody (YA5316)

SHP-1 Antibody (YA5316) is a mouse-derived and non-conjugated monoclonal antibody, targeting to SHP-1. It can be applicated for WB, IP assays, in the background of human.

SHP-1 protein acts as a critical modulator of signaling pathways initiated by tyrosine phosphorylated cell surface receptors, including KIT and the EGF receptor/EGFR. Additionally, it enhances the inhibition of mast cell activation mediated by the Lilrb4a receptor. The SH2 regions of SHP-1 may engage with other cellular components, influencing its phosphatase activity against interacting substrates. Notably, in collaboration with MTUS1, SHP-1 induces UBE2V2 expression in response to angiotensin II stimulation. Beyond these regulatory functions, SHP-1 plays a key role in hematopoiesis, further emphasizing its significance in the intricate network of cellular processes and signaling events.

P29350

Observed band size: 68 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:1000

WB, IP

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human SHP-1 protein fragments expressed in E.coli.