RBPJK Antibody (YA099)

Cat. No.: HY-P80305: Data Sheet User Guide for Antibodies
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RBPJK Antibody (YA099) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RBPJK.

For research use only. We do not sell to patients.

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10 μL		Ask For Quote & Lead Time
50 μL		Ask For Quote & Lead Time
100 μL		Ask For Quote & Lead Time

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RBPJK Antibody (YA099) Featured Recommendations:

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

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Description	RBPJK Antibody (YA099) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RBPJK.
Background	RBPJK is a transcriptional regulator that plays a central role in the Notch signaling pathway, which mediates cell-cell communication and regulates diverse cell-fate decisions. It functions as a transcriptional repressor when not bound to Notch proteins, but acts as a transcriptional activator upon association with the Notch intracellular domain (NICD), promoting the expression of Notch target genes. Its repressive or activating effects are likely mediated by recruiting chromatin remodeling complexes containing histone deacetylases or histone acetylases, respectively. RBPJK specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence and methylated DNA. Under hypoxic conditions (4% oxygen), it binds to the oxygen-responsive element of COX4I2 and activates its transcription. Additionally, it negatively regulates the phagocyte oxidative burst during bacterial infection by repressing the transcription of NADPH oxidase subunits (by similarity).
Tag	Free
Gene ID	3516 [NCBI]
SwissProt ID	Q06330
Molecular Weight	Predicted band size: 56 kDa; Observed band size: 60 kDa
Purity	Protein A affinity purified.
Subcellular Location	Cytoplasm. Nucleus.
Conjugation	Non-conjugated
Modification	Unmodified
Research Field	Neuroscience
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human
Dilution Ratio	WB: 1:1,000-1:5,000
Application	WB
Appearance	Liquid
Formulation	Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	Synthetic peptide corresponding to Human RBPJK.AA range:81-184.
Database	Entrez Gene: 3516 Human SwissProt: Q06330 Human OMIM: 614814 Human
Documentation	Data Sheet (234 KB) User Guide for Antibodies (1077 KB)

RBPJK Antibody (YA099) Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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RBPJK Antibody (YA099)

RBPJK Antibody (YA099) Featured Recommendations:

Biological Activity

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RBPJK Antibody (YA099) Related Classifications

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