Raptor Antibody (YA5994)

Raptor Antibody (YA5994) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Raptor.

Raptor is a core component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. Upon nutrient/growth factor/amino acid stimulation, mTORC1 is recruited to lysosomal membranes and phosphorylates substrates like ribosomal protein S6 kinase (RPS6KB1/RPS6KB2) and EIF4EBP1 (4E-BP1) to enhance protein/lipid/nucleotide synthesis, while suppressing catabolic pathways via phosphorylation of autophagy initiators ULK1/ATG13 and transcription factor TFEB (a master regulator of lysosomal biogenesis and autophagy). Within mTORC1, RPTOR functions as both a molecular scaffold—mediating lysosomal recruitment through Rag GTPase (RagA/RRAGA etc.) interactions—and a substrate-specific adaptor that directs TOS motif-containing proteins to MTOR's kinase domain for phosphorylation. The complex is inhibited during starvation/amino acid depletion. Additionally, mTORC1 regulates processes such as odontoblast/osteoclast differentiation (by similar), and its role in excitatory neuronal transmission underlies the prosocial effects of the psychoactive drug LSD (by similar).

Q8N122

Predicted band size: 149 kDa; Observed band size: 149 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse

IHC: 1:200-1:1000; WB: 1:1000-1:5000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG