PTPRD Antibody (YA3893)

PTPRD Antibody (YA3893) is a mouse-derived and non-conjugated IgG1 antibody, targeting to PTPRD. It can be applicated for FC, ELISA assays, in the background of human.

PKCE, a calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase, plays vital roles in regulating various cellular processes associated with cytoskeletal proteins. It is involved in cell adhesion, motility, migration, cell cycle, neuron growth, ion channel regulation, immune response, cancer cell invasion, and apoptosis. PKCE mediates integrin-dependent signaling, influencing cell adhesion to the extracellular matrix, and phosphorylates proteins such as MARCKS, PTK2/FAK, vimentin (VIM), keratin-8 (KRT8), and IQGAP1 to modulate diverse cellular functions. It contributes to cell migration in response to growth factors, participates in cytokinesis, regulates myofilament function in cardiac myocytes, and is implicated in the pathogenesis of dilated cardiomyopathy. Additionally, PKCE influences neurite outgrowth, synaptic potentiation, and the immune response by phosphorylating various substrates, including GABRG2, TRPV1, CACNA1B, STAT3, TICAM2/TRAM, and NLRP5/MATER. It emerges as a multifaceted kinase with wide-ranging impacts on cellular physiology and pathology.

P23468

Predicted band size: 214.8 kDa; Observed band size: 175 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

FC: 1/200-1/400; ELISA: 1/10000

FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human PTPRD (AA: extra 1077-1265) expressed in E. Coli.