Calcineurin A Antibody (YA5147)

Calcineurin A Antibody (YA5147) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Calcineurin A.

Calcineurin A is a calcium-dependent, calmodulin-stimulated protein phosphatase essential for intracellular Ca²⁺-mediated signal transduction. It recognizes substrates containing PxIxIT and/or LxVP motifs, participating in diverse biological processes including mitochondrial dynamics (e.g., DNM1L dephosphorylation), transcriptional regulation (e.g., NFATC1 activation/ELK1 inhibition), neuronal Ca²⁺ release (By similarity: CACNA1B/CAV2.2 modulation), HSPB1 dephosphorylation (By similarity), and kidney development/function (By similarity: e.g., AQP2 membrane trafficking). It also contributes to immune responses (By similarity: T-cell proliferation), bone formation (By similarity: osteoblast differentiation), and muscle fiber specification (By similarity: NFATC1 signaling). Recent studies reveal its roles in CRTC2/TFEB nuclear translocation via dephosphorylation, negative regulation of MAP3K14/NIK pathway (By similarity: RELA/RELB nuclear exclusion), and SLC9A1 activity inhibition.

Q08209

Predicted band size: 59 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

WB: 1:1000-1:2000

WB

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human PP2B-Aα protein fragments expressed in E.coli.