Plexin A1 Antibody (YA4563)

Plexin A1 Antibody (YA4563) is a mouse-derived and non-conjugated IgG1 antibody, targeting to PLXNA1. It can be applicated for ICC/IF, FC, ELISA assays, in the background of human.

PLXNA1 protein serves as a coreceptor for SEMA3A, SEMA3C, SEMA3F, and SEMA6D, playing an essential role in signaling by class 3 semaphorins and subsequent cytoskeleton remodeling. It is integral to processes such as axon guidance, invasive growth, and cell migration. In the presence of class 3 semaphorins, PLXNA1 forms a complex with a neuropilin, and this interaction modulates the affinity of the complex for specific semaphorins. The cytoplasmic domain of PLXNA1 is crucial for activating downstream signaling events within the cytoplasm. Notably, the protein interacts directly with neuropilins NRP1 and NRP2, and it also engages with FARP2, RND1, and KDR/VEGFR2. The binding of SEMA3A to PLXNA1 leads to the dissociation of FARP2, highlighting the intricate regulatory role of PLXNA1 in semaphorin-mediated cellular responses.

Q9UIW2

Predicted band size: 211 kDa; Observed band size: 211 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IF: 1/100-1/500; FC: 1/200-1/400; ELISA: 1/10000

ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human PLXNA1 (AA: 1100-1200) expressed in E. Coli.