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  4. Monoclonal Antibodies Recombinant Antibodies
  5. PIM2 Antibody (YA2750)

PIM2 Antibody (YA2750) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2750), targeting PIM2, with a predicted molecular weight of 34 kDa (observed band size: 37 kDa). PIM2 Antibody (YA2750) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

PIM2 Antibody (YA2750) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2750), targeting PIM2, with a predicted molecular weight of 34 kDa (observed band size: 37 kDa). PIM2 Antibody (YA2750) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.
Background

The PIM2 protein, a proto-oncogene with serine/threonine kinase activity, plays a crucial role in cell survival and proliferation by exerting its oncogenic activity through multiple mechanisms. It regulates MYC transcriptional activity, cell cycle progression, and cap-dependent protein translation. Phosphorylation of MYC by PIM2 enhances MYC protein stability, resulting in increased transcriptional activity and potentially explaining the robust synergism between these two oncogenes in tumorigenesis. PIM2 also mediates survival signaling by phosphorylating the pro-apoptotic protein BAD, leading to the release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Moreover, PIM2 positively regulates the I-kappa-B kinase/NF-kappa-B cascade, promoting cell survival in response to various proliferative signals. It facilitates growth factor-independent proliferation by phosphorylating cell cycle factors such as CDKN1A and CDKN1B. Additionally, PIM2 is involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
Gene ID
SwissProt ID
Synonyms
PIM2; Serine/threonine-protein kinase pim-2; Pim-2h
Molecular Weight

Predicted band size: 34 kDa; Observed band size: 37 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Signal Transduction
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000;IF: 1/50-1/200;IP: 1/50
Application

WB, ICC/IF, IP
Appearance

Liquid
Formulation

Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthesized peptide derived from human PIM2
Database

Entrez Gene: 11040 Human ; 18715 Mouse ; 317366 Rat

SwissProt: Q9P1W9 Human ; Q62070 Mouse ;

OMIM: 300295 Human

Documentation
SDS (251 KB)

COA (191 KB)

User Guide for Antibodies (1077 KB)

PIM2 Antibody (YA2750) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PIM2 Antibody (YA2750)
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HY-P83005
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