PI3 Kinase p85 alpha Antibody (YA6337)

PI3 Kinase p85 alpha Antibody (YA6337) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PI3 Kinase P85α. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

PI 3 Kinase p85 alpha binds to activated (phosphorylated) protein-Tyr kinases via its SH2 domain, acting as an adapter to mediate the association of the p110 catalytic unit with the plasma membrane. It is essential for insulin-stimulated increases in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Additionally, it plays a significant role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA, and PDGFRB, as well as in ITGB2 signaling. Similarly, it modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in an ER stress- and/or insulin-dependent manner during metabolic overloading in the liver, thereby contributing to improved glucose tolerance.

P27986

Predicted band size: 84 kDa; Observed band size: 84 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC: 1:200-1000; WB: 1:1000-5000; ICC/IF: 1:200-1000; ELISA: 1:5000-20000; IP: 1:50-200

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG