PI3 Kinase p85 β Antibody (YA5277)

PI3 Kinase p85 β Antibody (YA5277) is a mouse-derived and non-conjugated monoclonal antibody, targeting to PI3K(p85β). It can be applicated for WB assays, in the background of human, mouse, rat.

PI3 Kinase p85 β is a regulatory subunit of phosphoinositide-3-kinase (PI3K), which phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 recruits PH domain-containing proteins, such as AKT1 and PDPK1, to the membrane, activating signaling cascades involved in cell growth, survival, proliferation, motility, and morphology. p85 β binds to activated (phosphorylated) protein-tyrosine kinases via its SH2 domain, acting as an adapter to mediate the association of the p110 catalytic unit with the plasma membrane. It also indirectly regulates autophagy and promotes nuclear translocation of XBP1 isoform 2 in an ER stress- and/or insulin-dependent manner during metabolic overloading, thereby improving glucose tolerance (By similarity).

O00459

Observed band size: 85 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

WB: 1:1000

WB

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human PI3 Kinase p85 beta protein fragments expressed in E.coli.