Phospho-SIRT1 (Ser47) Antibody (YA1036)

Phospho-SIRT1 (Ser47) Antibody (YA1036) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1036), targeting Phospho-SIRT1 (Ser47), with a predicted molecular weight of 82 kDa (observed band size: 110 kDa). Phospho-SIRT1 (Ser47) Antibody (YA1036) can be used for WB, IHC-P, ICC/IF experiment in human background.

SIRT1, a NAD-dependent protein deacetylase, orchestrates the integration of various cellular functions, including cell cycle progression, response to DNA damage, metabolism, apoptosis, and autophagy, by modulating the acetylation status of numerous target proteins. Functioning as a sensor of the NAD(+)/NADH ratio, SIRT1 responds to changes in cellular energetics induced by factors such as glucose deprivation and caloric restriction. Its wide-ranging impact encompasses chromatin remodeling through histone deacetylation, ultimately leading to transcriptional regulation. SIRT1 engages in diverse interactions, deacetylating transcription factors, coregulators, and histones, thereby exerting both positive and negative regulation on target gene expression. Additionally, SIRT1 is implicated in critical processes such as DNA damage response, autophagy, circadian rhythm regulation, and metabolic homeostasis. Its multifaceted roles extend to the regulation of various cellular pathways and the maintenance of genomic integrity, highlighting its significance in cellular physiology and stress response.

Q96EB6

Predicted band size: 82 kDa; Observed band size: 110 kDa

Affinity Chromatography

Non-conjugated

Phosphorylated

Cell Biology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200

WB, IHC-P, ICC/IF

Liquid

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human Phospho-SIRT1 (S47)