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  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. Phospho-mTOR (Ser2448) Antibody (YA691)

Phospho-mTOR (Ser2448) Antibody (YA691)

Cat. No.: HY-P80469
COA
SDS
User Guide for Antibodies Technical Support

Phospho-mTOR (Ser2448) Antibody (YA691) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Phospho-mTOR (Ser2448).

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Phospho-mTOR (Ser2448) Antibody (YA691) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Phospho-mTOR (Ser2448).
Background

mTOR is a serine/threonine protein kinase that serves as a central regulator of cellular metabolism, growth, and survival in response to hormones, growth factors, nutrients, energy, and stress signals. It functions through two structurally and functionally distinct complexes, mTORC1 and mTORC2. mTORC1 is recruited to the lysosome membrane upon nutrient or growth factor stimulation, promoting protein, lipid, and nucleotide synthesis by phosphorylating key regulators of translation (e.g., EIF4EBP1, RPS6KB1/2) while suppressing autophagy (e.g., via ULK1, DAP, AMBRA1 phosphorylation). mTORC2 responds to growth factors by phosphorylating AGC kinase family members (e.g., AKT, PKC, SGK1) to regulate proliferation, cytoskeletal organization, and lipogenesis. Additionally, mTOR modulates mitochondrial biogenesis (by similar), insulin signaling (by similar), circadian rhythms (by similar), and pyroptosis (e.g., GSDMD oligomerization).
Tag

Free
Gene ID
SwissProt ID
Molecular Weight

Predicted band size: 289 kDa; Observed band size: 289 kDa
Purity

Protein G affinity purified.
Subcellular Location

Lysosome, Mitochondrion outer membrane, Endoplasmic reticulum membrane, Cytoplasm.
Conjugation

Non-conjugated
Modification

Phosphorylated
RRID
Research Field

Cell Biology
Product Categories

Primary Antibody; Mouse Monoclonal Antibody
Clonality

Monoclonal
Host

Mouse
Reactivity

Human, Mouse
Dilution Ratio

WB: 1:500-1:2,000 ;IHC: 1:50-1:200
Application

WB, IHC-P
Appearance

Liquid
Formulation

Supplied in 1*PBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG1
Sensitivity

Endogenous
Immunogen

Synthetic peptide corresponding to Human mTOR.AA range:2430-2480.
Database

Entrez Gene: 2475 Human ; 56717 Mouse ;

SwissProt: P42345 Human ; Q9JLN9 Mouse ;

OMIM: 616638 Human

Documentation
SDS (251 KB)

COA (191 KB)

User Guide for Antibodies (1077 KB)

Phospho-mTOR (Ser2448) Antibody (YA691) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Phospho-mTOR (Ser2448) Antibody (YA691)
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