Phospho-Moesin (Thr558) Antibody (YA2614)

Cat. No.: HY-P82869: Data Sheet COA
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Phospho-Moesin (Thr558) Antibody (YA2614) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2614), targeting Phospho-Moesin (Thr558), with a predicted molecular weight of 68 kDa (observed band size: 68 kDa). Phospho-Moesin (Thr558) Antibody (YA2614) can be used for WB, IHC-P experiment in human, rat background.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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Phospho-Moesin (Thr558) Antibody (YA2614) Featured Recommendations:

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

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Description	Phospho-Moesin (Thr558) Antibody (YA2614) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2614), targeting Phospho-Moesin (Thr558), with a predicted molecular weight of 68 kDa (observed band size: 68 kDa). Phospho-Moesin (Thr558) Antibody (YA2614) can be used for WB, IHC-P experiment in human, rat background.
Background	Moesin, an Ezrin-radixin-moesin (ERM) family protein, serves as a crucial link between the actin cytoskeleton and the plasma membrane, thereby influencing the structure and function of specific domains in the cell cortex. Functioning as a tether for actin filaments, Moesin undergoes oscillation between a resting and an activated state, establishing transient interactions with the actin cytoskeleton. Upon phosphorylation of its C-terminal threonine, Moesin becomes activated, leading to interactions with F-actin and subsequent cytoskeletal rearrangements. These rearrangements play a pivotal role in regulating various cellular processes, including cell shape determination, membrane transport, and signal transduction. Moesin's significance is particularly pronounced in immunity, impacting both T and B-cell homeostasis and self-tolerance, and regulating lymphocyte egress from lymphoid organs. Additionally, Moesin modulates phagolysosomal biogenesis in macrophages and participates in immunologic synapse formation. The protein adopts a closed conformation (inactive form) through a head-to-tail association of its N-terminal and C-terminal halves, rendering it incapable of actin or membrane-binding in this state.
Gene ID	4478 [NCBI]
SwissProt ID	P26038
Synonyms	MSN; Moesin; Membrane-organizing extension spike protein; RDX; Radixin; EZR; VIL2; Ezrin; Cytovillin; Villin-2; p81
Molecular Weight	Predicted band size: 68 kDa; Observed band size: 68 kDa
Purity	Affinity Purified
Conjugation	Non-conjugated
Modification	Phosphorylated
RRID	AB_3104962
Research Field	Signal Transduction
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human, Rat
Dilution Ratio	WB: 1/500-1/1000;IHC: 1/50-1/100
Application	WB, IHC-P
Appearance	Liquid
Formulation	Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	A synthetic phosphopeptide corresponding to residues surrounding Thr558 of human Moesin
Database	Entrez Gene: 4478 Human ; 17698 Mouse ; 81521 Rat SwissProt: P26038 Human ; P26041 Mouse ; O35763 Rat OMIM: 300988 Human
Documentation	Select Batch: Data Sheet (235 KB) SDS (251 KB) COA (206 KB) User Guide for Antibodies (1077 KB)

Phospho-Moesin (Thr558) Antibody (YA2614) Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Phospho-Moesin (Thr558) Antibody (YA2614)

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