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  5. Phospho-JAK2 (Tyr1007+Tyr1008) Antibody (YA181)

Phospho-JAK2 (Tyr1007+Tyr1008) Antibody (YA181)

Cat. No.: HY-P80467
COA
SDS
User Guide for Antibodies Technical Support

Phospho-JAK2 (Tyr1007+Tyr1008) Antibody (YA181) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-JAK2 (Tyr1007+Tyr1008).

For research use only. We do not sell to patients.

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50 μL In-stock
100 μL In-stock
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Phospho-JAK2 (Tyr1007+Tyr1008) Antibody (YA181) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-JAK2 (Tyr1007+Tyr1008).
Background

JAK2 is a non-receptor tyrosine kinase involved in diverse processes including cell growth, development, differentiation, and histone modifications, playing essential roles in both innate and adaptive immunity signaling. In the cytoplasm, it mediates signal transduction by associating with type I receptors (e.g., GHR, PRLR, LEPR, EPOR, MPL/TPOR) or type II receptors (e.g., IFN-α/β/γ and interleukin receptors). Upon ligand binding, JAK2 phosphorylates receptor cytoplasmic tails to create docking sites for STAT proteins, which it further phosphorylates to enable their nuclear translocation and transcriptional activation. For instance, during erythropoiesis, EPO stimulation triggers JAK2 autophosphorylation and EPOR association, leading to STAT5 activation and erythropoiesis-related gene expression. JAK2 also participates in cellular retinol-induced STAT5 activation, angiotensin-2-driven ARHGEF1 phosphorylation, cell cycle regulation (via CDKN1B phosphorylation), and TEC-coordinated FOS transcription. In the nucleus, it phosphorylates histone H3 at Tyr-41 (H3Y41ph), excluding CBX5 (HP1α) from chromatin, and enhances KCNA3 potassium channel activity.
Tag

Free
Gene ID
SwissProt ID
Molecular Weight

Predicted band size: 131 kDa; Observed band size: 120 kDa
Purity

Protein A affinity purified.
Subcellular Location

Nucleus, Endomembrane system, Cytoplasm.
Conjugation

Non-conjugated
Modification

Phosphorylated
RRID
Research Field

Cell Biology
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1:500-1:1000; ICC: 1:50-1:200; IHC-P: 1:200; IP: Use at an assay dependent concentration.
Application

WB, ICC/IF, IHC-P, IP
Appearance

Liquid
Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

Synthetic phosphopeptide corresponding to residues surrounding Tyr1007 and 1008 of Human JAK2.The exact sequence is proprietary to MCE.
Database

Entrez Gene: 3717 Human ; 16452 Mouse ; 24514 Rat

SwissProt: O60674 Human ; Q62120 Mouse ; Q62689 Rat

OMIM: 600880 Human

Documentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

Phospho-JAK2 (Tyr1007+Tyr1008) Antibody (YA181) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Phospho-JAK2 (Tyr1007+Tyr1008) Antibody (YA181)
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