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  5. Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595)

Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595)

Cat. No.: HY-P82850
COA
SDS
User Guide for Antibodies Technical Support

Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2595), targeting Phospho-Glucocorticoid Receptor (Ser226), with a predicted molecular weight of 86 kDa (observed band size: 94 kDa). Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595) can be used for WB, IHC-P experiment in human, rat background.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2595), targeting Phospho-Glucocorticoid Receptor (Ser226), with a predicted molecular weight of 86 kDa (observed band size: 94 kDa). Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595) can be used for WB, IHC-P experiment in human, rat background.
Background

The Glucocorticoid Receptor (GR) is a receptor for glucocorticoids (GC) with a dual mode of action: functioning as a transcription factor that binds to glucocorticoid response elements (GRE) in both nuclear and mitochondrial DNA, and as a modulator of other transcription factors. It regulates inflammatory responses, cellular proliferation, and differentiation, and is involved in chromatin remodeling. GR also promotes rapid mRNA degradation by binding to target mRNA 5' UTRs and interacting with PNRC2 in a ligand-dependent manner, recruiting UPF1 and DCP1A to induce RNA decay. Additionally, GR acts as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and plays a critical role in hepatic GR-mediated body growth regulation (by similar). GR exhibits both transcriptional activation and repression activities, mediates glucocorticoid-induced apoptosis, and ensures accurate chromosome segregation during mitosis. It may function as a tumor suppressor and negatively regulate adipogenesis by controlling lipolytic and antilipogenic gene expression (by similar). Different isoforms (e.g., Alpha) display varying functions, including transcriptional activity, hormone-binding capacity, and roles in glucose metabolism regulation.
Gene ID
SwissProt ID
Synonyms
NR3C1; GRL; Glucocorticoid receptor; GR; Nuclear receptor subfamily 3 group C member 1
Molecular Weight

Predicted band size: 86 kDa; Observed band size: 94 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Phosphorylated
RRID
Research Field

Signal Transduction
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Rat
Dilution Ratio

WB: 1/500-1/1000;IHC: 1/50-1/100
Application

WB, IHC-P
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser226 of human Glucocorticoid Receptor
Database

Entrez Gene: 2908 Human ; 14815 Mouse ; 24413 Rat

SwissProt: P04150 Human ; P06537 Mouse ; P06536 Rat

OMIM: 615962 Human

Documentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595)
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