Phospho-CaMKIIβ/γ/δ Antibody (YA5758)

Phospho-CaMKIIβ/γ/δ Antibody (YA5758) is a mouse-derived and non-conjugated monoclonal antibody, targeting to CaMKIIβ/γ/δ. It can be applicated for IHC-P, ICC/IF assays, in the background of human, rat, mouse.

CaMKII β is a calcium/calmodulin-dependent protein kinase that operates autonomously following Ca²⁺/calmodulin binding and autophosphorylation, playing roles in dendritic spine/synapse formation, neuronal plasticity, and regulation of sarcoplasmic reticulum Ca²⁺ transport in skeletal muscle. In neurons, it structurally reorganizes the actin cytoskeleton during plasticity by kinase-independent actin filament bundling, enabling proper targeting of CaMK2A to promote synaptic plasticity underlying long-term potentiation (LTP) and hippocampus-dependent learning. It facilitates dendritic arborization in developing hippocampal neurons and remodeling in mature neurons, while also regulating neuronal migration. In skeletal muscle, it modulates function during exercise: regulating SR Ca²⁺ transport in slow-twitch fibers and controlling Ca²⁺ release via phosphorylation of triadin and phospholamban in fast-twitch fibers. Upon IFN-γ stimulation, it phosphorylates STAT1 to activate JAK-STAT signaling (By similarity). Under ER stress, it phosphorylates RETREG1 at Ser-151 to enhance its oligomerization and reticulophagy activity.

Q13554;Q13555;Q13557

Observed band size: 50 kDa

affinity chromatography.

Non-conjugated

Phosphorylated

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Rat, Mouse

IHC: 1:100-200; ICC/IF: 1:50-200

IHC-P, ICC/IF

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Synthetic Peptide of CaMKIIβ/γ/δ (Phospho Thr287)