PGC-1α Antibody (YA5018)

PGC-1α Antibody (YA5018) is a mouse-derived and non-conjugated monoclonal antibody, targeting to PGC-1α. It can be applicated for WB, ELISA assays, in the background of human.

PGC-1α is a transcriptional coactivator for steroid receptors and nuclear receptors (e.g., PPARG and thyroid hormone receptors), greatly enhancing their transcriptional activity on the uncoupling protein promoter. It regulates key mitochondrial genes involved in adaptive thermogenesis and serves as a central coordinator of metabolic reprogramming by modulating genes related to glucose and fatty acid metabolism. PGC-1α is essential for gluconeogenesis, collaborating with FOXO1 to promote hepatic gluconeogenic programs. In skeletal muscle, it induces PERM1 expression in an ESRRA-dependent manner. It also integrates circadian rhythms with energy metabolism (by similar), coactivating RORA and RORC to regulate oscillatory expression of clock genes (e.g., BMAL1 and NR1D1) and metabolic genes (e.g., PDK4 and PEPCK) (by similar).

Q9UBK2

Predicted band size: 91 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human PGC-1α expressed in E. Coli.