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  4. PEG10 Antibody (YA5015)

PEG10 Antibody (YA5015)

Cat. No.: HY-P85323
User Guide for Antibodies Technical Support

PEG10 Antibody (YA5015) is a mouse-derived and non-conjugated monoclonal antibody, targeting to PEG10. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

For research use only. We do not sell to patients.

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50 μL   Get quote  
100 μL   Get quote  

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

PEG10 Antibody (YA5015) is a mouse-derived and non-conjugated monoclonal antibody, targeting to PEG10. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

Background

PEG10 is a retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids. It forms virion-like extracellular vesicles that encapsulate its own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA. The protein binds its own mRNA in the 5'-UTR region, near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences, and at the beginning of the 3'-UTR region. PEG10 is involved in placenta formation (by similar) and is required for trophoblast stem cell differentiation. It also plays a role in the immediate early stage of adipocyte differentiation (by similar). Overexpressed in many cancers, PEG10 enhances tumor progression by promoting cell proliferation through driving cell cycle progression from G0/G1 phase. It further supports cancer progression by inhibiting the TGF-beta signaling pathway, potentially via interaction with the TGF-beta receptor ACVRL1. PEG10 may bind to the 5'-GCCTGTCTTT-3' DNA sequence in the myelin basic protein (MBP) promoter's MB1 domain, though additional evidence is needed to confirm this (by similar).

Gene ID
SwissProt ID
Synonyms
PEG10; EDR; KIAA1051; MAR2; MART2; MEF3L1; RGAG3; Retrotransposon-derived protein PEG10; Embryonal carcinoma differentiation-regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3-like protein 1; MEF3-lik
Molecular Weight

Predicted band size: 80 kDa;

Purity

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Product Categories

Primary Antibody; Mouse Monoclonal Antibody

Clonality

Monoclonal

Host

Mouse

Reactivity

Human

Dilution Ratio

WB: 1:500-1:2000; IHC: 1:200-1:1000; ICC/IF: 1:200-1:1000; ELISA: 1:10000

Application

WB, IHC-P, ICC/IF, ELISA

Appearance

Liquid

Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Immunogen

Purified recombinant fragment of PEG10 (aa1-120) expressed in E. Coli.

Documentation

PEG10 Antibody (YA5015) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PEG10 Antibody (YA5015)
Cat. No.:
HY-P85323
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