PDIA6 Antibody (YA237)

Cat. No.: HY-P80271: Data Sheet User Guide for Antibodies
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PDIA6 Antibody (YA237) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PDIA6.

For research use only. We do not sell to patients.

Size	Price	Stock
10 μL		Ask For Quote & Lead Time
50 μL		Ask For Quote & Lead Time
100 μL		Ask For Quote & Lead Time

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PDIA6 Antibody (YA237) Featured Recommendations:

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

Biological Activity
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Description	PDIA6 Antibody (YA237) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PDIA6.
Background	The PDIA6 protein exhibits diverse functions, acting as a chaperone that inhibits the aggregation of misfolded proteins, thereby contributing to protein quality control. Moreover, it negatively regulates the unfolded protein response (UPR) by binding to UPR sensors like ERN1, leading to the inactivation of ERN1 signaling. Additionally, PDIA6 may modulate the UPR through the EIF2AK3 UPR sensor. Beyond its role in protein homeostasis, PDIA6 plays a significant role in platelet aggregation and activation induced by various agonists, such as convulxin, collagen, and thrombin. These multifaceted functions underscore the importance of PDIA6 in cellular processes related to protein folding, quality control, and platelet activation. Further research is needed to unravel the specific molecular mechanisms underlying these diverse functions, providing insights into the broader regulatory roles of PDIA6 in cellular physiology.
Tag	Free
Gene ID	10130 [NCBI]
SwissProt ID	Q15084
Molecular Weight	Predicted band size: 48kDa; Observed band size: 48kDa
Purity	affinity purified by Protein A
Subcellular Location	Endoplasmic reticulum lumen, Cell membrane, Melanosome.
Conjugation	Non-conjugated
Modification	Unmodified
Product Categories	Primary Antibody; Monoclonal Antibody
Clonality	Monoclonal, Recombinant
Host	Rabbit
Reactivity	Human, Mouse, Rat
Dilution Ratio	WB: 1:500-2000; IHC-P: 1:100-500; IHC-F: 1:100-500; IF-Tissue: 1:100-500; ICC/IF: 1:50-200;
Application	WB, IHC-P, IHC-F, IF-Tissue, ICC/IF
Appearance	Liquid
Formulation	Supplied in10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	A synthesized peptide derived from human PDIA6. The exact sequence is proprietary to MCE.
Database	Entrez Gene: 10130 Human ; 71853 Mouse ; 286906 Rat SwissProt: Q15084 Human ; Q922R8 Mouse ; Q63081 Rat OMIM: 611099 Human
Documentation	Data Sheet (235 KB) User Guide for Antibodies (1077 KB)

PDIA6 Antibody (YA237) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PDIA6 Antibody (YA237)

PDIA6 Antibody (YA237) Featured Recommendations:

Biological Activity

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PDIA6 Antibody (YA237) Related Classifications

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