PDGFR alpha Antibody (YA3824)

PDGFR alpha Antibody (YA3824) is a mouse-derived and non-conjugated IgG1 antibody, targeting to PDGFRA. It can be applicated for ICC/IF, FC, ELISA assays, in the background of human, mouse, monkey.

CD140a is a tyrosine-protein kinase that functions as a cell-surface receptor for PDGFA, PDGFB, and PDGFC, playing pivotal roles in embryonic development, cell proliferation, survival, and chemotaxis regulation. Its context-dependent actions include promoting or inhibiting cell proliferation/migration. It is essential for bone marrow-derived mesenchymal stem cell differentiation, embryonic skeleton development, cephalic closure, gastrointestinal mucosa formation, mesenchymal cell recruitment, and intestinal villi development. It contributes to wound healing via chemotaxis/migration and regulates platelet activation, granule secretion, and thrombin-induced aggregation. Ligand binding (PDGFA/PDGFB homo/heterodimers or PDGFC homodimers) triggers diverse signaling cascades modulated by PDGFRA/PDGFRB heterodimerization. It phosphorylates PIK3R1 (activating AKT1), PLCG1 (generating DAG/IP3 for Ca2+ mobilization and PKC activation), and PTPN11, while activating HRAS, MAPK1/ERK2/MAPK3/ERK1, and STAT1/STAT3/STAT5. Signaling is attenuated by phosphatase-mediated dephosphorylation and receptor internalization.

P16234

Predicted band size: 123 kDa; Observed band size: 190 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human, Mouse, Monkey

IF: 1/50-1/500; FCM: 1/200-1/400; ELISA: 1/10000

ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human PDGFRA (AA: 361-528) expressed in E. Coli.