PDGFR alpha Antibody (YA6011)

PDGFR alpha Antibody (YA6011) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PDGFR-α. It can be applicated for WB, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

CD140a is a tyrosine-protein kinase that functions as a cell-surface receptor for PDGFA, PDGFB, and PDGFC, playing pivotal roles in embryonic development, cell proliferation, survival, and chemotaxis regulation. Its context-dependent actions include promoting or inhibiting cell proliferation/migration. It is essential for bone marrow-derived mesenchymal stem cell differentiation, embryonic skeleton development, cephalic closure, gastrointestinal mucosa formation, mesenchymal cell recruitment, and intestinal villi development. It contributes to wound healing via chemotaxis/migration and regulates platelet activation, granule secretion, and thrombin-induced aggregation. Ligand binding (PDGFA/PDGFB homo/heterodimers or PDGFC homodimers) triggers diverse signaling cascades modulated by PDGFRA/PDGFRB heterodimerization. It phosphorylates PIK3R1 (activating AKT1), PLCG1 (generating DAG/IP3 for Ca2+ mobilization and PKC activation), and PTPN11, while activating HRAS, MAPK1/ERK2/MAPK3/ERK1, and STAT1/STAT3/STAT5. Signaling is attenuated by phosphatase-mediated dephosphorylation and receptor internalization.

P16234

Predicted band size: 123 kDa; Observed band size: 190 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

WB: 1:2000-1:10000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200;

WB, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG