PDCD4 Antibody (YA240)

Cat. No.: HY-P80269: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

PDCD4 Antibody (YA240) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PDCD4.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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PDCD4 Antibody (YA240) Featured Recommendations:

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

Biological Activity
Technical Parameters
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Description	PDCD4 Antibody (YA240) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PDCD4.
Background	PDCD4, as a multifaceted protein, plays a pivotal role in inhibiting translation initiation and cap-dependent translation, potentially by disrupting the interaction between EIF4A1 and EIF4G and impeding the helicase activity of EIF4A. Moreover, it modulates JUN kinase activation and down-regulates MAP4K1 expression, thereby inhibiting crucial events associated with invasion and tumorigenesis. Functioning as a tumor suppressor, PDCD4 demonstrates the capacity to hinder neoplastic transformation induced by tumor promoters. It binds RNA and interacts with EIF4A1, EIF4A2, and EIF4G1, forming complexes that influence the translation machinery. Phosphorylation of PDCD4 facilitates interactions with BTRC and FBXW11, adding a layer of complexity to its regulatory functions in cellular processes, including apoptosis and tumor suppression.
Tag	Free
Gene ID	27250 [NCBI]
SwissProt ID	Q53EL6
Molecular Weight	Predicted band size: 52 kDa;Observed band size: 56 kDa
Purity	Protein A affinity purified.
Subcellular Location	Nucleus. Cytoplasm.
Conjugation	Non-conjugated
Modification	Unmodified
RRID	AB_3102391
Research Field	Cell Biology
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human, Mouse
Dilution Ratio	WB: 1:500 ;ICC: 1:20-1:50 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Application	WB, ICC/IF, IHC-P, FC
Appearance	Liquid
Formulation	Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	Synthetic peptide corresponding to Human PDCD4.AA range:425-469.
Database	Entrez Gene: 27250 Human ; 18569 Mouse ; SwissProt: Q53EL6 Human ; Q61823 Mouse ; OMIM: 608610 Human
Documentation	Select Batch: Data Sheet (235 KB) SDS (251 KB) COA (205 KB) User Guide for Antibodies (1077 KB)

PDCD4 Antibody (YA240) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PDCD4 Antibody (YA240)

PDCD4 Antibody (YA240) Featured Recommendations:

Biological Activity

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PDCD4 Antibody (YA240) Related Classifications

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