PARL Antibody (YA5007)

PARL Antibody (YA5007) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PARL.

PARL emerges as a pivotal player in the intricate orchestration of cellular processes, particularly in the control of apoptosis during postnatal growth. Its essential role lies in the proteolytic processing of an antiapoptotic form of OPA1, preventing the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals. Additionally, PARL is indispensable for the maturation of PINK1, facilitating its transformation into the 52kDa mature form after cleavage by mitochondrial-processing peptidase (MPP). Notably, PARL exhibits versatility by mediating the cleavage of serine/threonine-protein phosphatase PGAM5 in damaged mitochondria, responding dynamically to the loss of mitochondrial membrane potential. Moreover, PARL contributes to the processing of CLPB, DIABLO/SMAC, STARD7, and TTC19, unveiling its multifaceted involvement in shaping mitochondrial function and morphology, with implications for apoptotic activity and cellular health.

Q9H300

Predicted band size: 42 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of PARL (aa112-167) expressed in E. Coli.