PAR4 Antibody (YA5006)

PAR4 Antibody (YA5006) is a mouse-derived and non-conjugated monoclonal antibody, targeting to PAR4. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

PAR4 is a pro-apoptotic protein that selectively induces apoptosis in cancer cells, sensitizing them to diverse apoptotic stimuli and causing tumor regression in animal models. It triggers apoptosis in certain cancer cells by activating the Fas pro-death pathway while simultaneously inhibiting NF-kappa-B transcriptional activity. PAR4 suppresses WT1-mediated transcriptional activation and enhances its repressive function, downregulating the anti-apoptotic protein BCL2 through interaction with WT1. Additionally, PAR4 appears to function as a transcriptional repressor itself and may directly regulate BACE1's cleavage activity of the amyloid precursor protein (APP).

Q96IZ0

Predicted band size: 37 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; IHC: 1:200-1:1000; ELISA: 1:10000; ICC/IF: 1:50-200

WB, IHC-P, ICC/IF, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of PAR4 (aa1-330) expressed in E. Coli.