PA28γ Antibody (YA5139)

PA28γ Antibody (YA5139) is a mouse-derived and non-conjugated monoclonal antibody, targeting to PA28γ. It can be applicated for WB, ICC/IF assays, in the background of human, mouse, dog, pig.

PA28γ is a subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, forming a doughnut-shaped homoheptamer that associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome while inhibiting the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. It facilitates the MDM2-p53/TP53 interaction, promoting ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, thereby limiting its accumulation and inhibiting apoptosis after DNA damage. PA28γ may also be involved in cell cycle regulation and mediates CCAR2- and CHEK2-dependent SIRT1 inhibition.

P61289

Predicted band size: 30 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Dog, Pig

WB: 1:1000-1:2000; ICC/IF: 1:100-1:500

WB, ICC/IF

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human PA28γ protein fragments expressed in E.coli.