ox-LDL Antibody

ox-LDL Antibody is an unconjugated, approximately 31 kDa, rabbit-derived, anti-ox-LDL polyclonal antibody. ox-LDL Antibody can be used for: ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, background without labeling.

ox-LDL is a receptor that mediates the recognition, internalization, and degradation of oxidatively modified low-density lipoprotein (oxLDL) by vascular endothelial cells. oxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, leading to pro-inflammatory responses, pro-oxidative conditions, and apoptosis. Its interaction with oxLDL triggers NF-kappa-B activation through increased intracellular reactive oxygen species production and various pro-atherogenic cellular responses, including reduced nitric oxide (NO) release, monocyte adhesion, and apoptosis. Beyond binding oxLDL, it functions as a receptor for HSP70 protein, facilitating antigen cross-presentation to naive T-cells in dendritic cells, thereby contributing to cell-mediated antigen cross-presentation. It also participates in inflammation by acting as a leukocyte-adhesion molecule at the vascular interface during endotoxin-induced inflammation. Additionally, it serves as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells, and both Gram-negative and Gram-positive bacteria. (Microbial infection) It may act as a receptor for Neisseria meningitidis adhesin A variant 3 (nadA).

Predicted band size: 31 kDa; Observed band size: 31 kDa

affinity purified

Secreted.

Non-conjugated

Unmodified

AB_3103082

Primary Antibody; Rabbit Polyclonal Antibody

Polyclonal

Rabbit

Human

ELISA: 1:5000-10000;IHC-P: 1:100-500;IHC-F: 1:100-500;Flow-Cyt: 2ug/Test;IF: 1:100-500

ELISA, IHC-P, IHC-F, FC, ICC/IF

IHC-P, FC

ICC/IF; ELISA

Liquid

Supplied in 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Full length protein from human plasma