OPN3 Antibody

OPN3 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to OPN3.

The OPN3 Protein, a G-protein coupled receptor, selectively activates G proteins via ultraviolet A (UVA) light-mediated activation in the skin. It binds both 11-cis retinal and all-trans retinal, regulating melanogenesis in melanocytes by inhibiting alpha-MSH-induced MC1R-mediated cAMP signaling and modulating calcium flux. OPN3 plays a crucial role in melanocyte survival through the regulation of intracellular calcium levels and subsequent BCL2/RAF1 signaling, while also influencing apoptosis via cytochrome c release and activation of the caspase cascade. In addition to being required for TYR and DCT blue light-induced complex formation in melanocytes, OPN3 is involved in keratinocyte differentiation and the UVA-mediated induction of calcium and mitogen-activated protein kinase signaling in dermal fibroblasts. It plays a role in light-mediated glucose uptake, mitochondrial respiration, and fatty acid metabolism in brown adipocyte tissues. Furthermore, OPN3 may contribute to the photorelaxation of airway smooth muscle cells through blue-light dependent GPCR signaling pathways. Its interaction with MC1R results in a decrease in MC1R-mediated cAMP signaling, ultimately reducing melanin production in melanocytes.

Q9H1Y3

Predicted band size: 45 kDa; Observed band size: 45 kDa

Affinity Purified

Cell membrane; Multi-pass membrane protein. Cytoplasm.

Unmodified

Primary Antibody; Rabbit Polyclonal Antibody

Polyclonal

Rabbit

Human, Mouse

WB: 1:500-1:2000; IHC: 1:100-1:300; ICC: 1:100-1:500

WB, IHC-P, ICC/IF

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Synthesized peptide derived from the Internal region of Human Encephalopsin.