NrCAM Antibody (YA4402)

NrCAM Antibody (YA4402) is a mouse-derived and non-conjugated IgG1 antibody, targeting to NRCAM. It can be applicated for ICC/IF, ELISA assays, in the background of human.

Neuronal cell adhesion molecule (NRCAM) is a member of the immunoglobulin superfamily and a cell adhesion protein with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. NRCAM is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth as a ankyrin-binding protein. NRCAM plays a role in mediating cell-cell contacts between Schwann cells and axons; the formation and maintenance of the nodes of Ranvier on myelinated axons; and normal clustering of sodium channels at heminodes. Therefore, NRCAM is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system while being crucial for the saltatory propagation of action potentials along myelinated axons. NRCAM is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of NRCAM have been associated with autism and addiction vulnerability.

Q92823

Predicted band size: 144 kDa; Observed band size: 144 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IF: 1/50 ELISA: 1/10000

ICC/IF, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human NRCAM (AA: 1192-1255) expressed in E. Coli.