2. Antibodies
  3. Primary Antibodies
  4. Polyclonal Antibodies
  5. NR0B2 Antibody

NR0B2 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 28 kDa, targeting to NR0B2. It can be used for WB,IHC-P,IF assays with tag free, in the background of Mouse, Rat.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

NR0B2 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 28 kDa, targeting to NR0B2. It can be used for WB,IHC-P,IF assays with tag free, in the background of Mouse, Rat.
Background

NR0B2 is a transcriptional regulator that functions as a negative regulator of receptor-dependent signaling pathways. It specifically inhibits the transactivation of nuclear receptors it interacts with and suppresses NEUROD1 transcriptional activity on E-box-containing promoters by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1. Additionally, NR0B2 is an essential component of the liver circadian clock, regulating NPAS2-mediated hepatic lipid metabolism through its interaction with NR1D1 and RORG (by similar). It also controls the circadian expression of cytochrome P450 (CYP) enzymes (by similar) and represses NR5A2 and HNF4A to down-regulate CYP2C38, inhibits NFLI3 to up-regulate CYP2A5, modulates the BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1, and CYP3A11, and suppresses NR1D1 to up-regulate CYP2B10, CYP4A10, and CYP4A14 (by similar).
Gene ID
SwissProt ID
Synonyms
NR0B2; NR0B2_HUMAN; Nr0b2a; Nuclear receptor subfamily 0 group B member 2; Nuclear receptor subfamily 0, group B, member 2a; Orphan nuclear receptor SHP; SHP; SHP-1; Shp1; Small heterodimer partner.
Molecular Weight

Predicted band size: 28 kDa;Observed band size: 28 kD
Purity

Protein A affinity purified.
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Product Categories

Primary Antibody; Rabbit Polyclonal Antibody
Clonality

Polyclonal
Host

Rabbit
Reactivity

Mouse, Rat
Predicted Reactivity

Human, Rabbit, Cow, Dog, Horse

Note: The predicted reactivity is for reference only, not as a product performance guarantee.
Dilution Ratio

WB: 1:500-2000; IHC-P: 1:100-500;IF: 1:100-500
Application

WB, IHC-P, ICC/IF
Appearance

Liquid
Formulation

Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Immunogen

KLH conjugated synthetic peptide derived from human NR0B2: 31-130/257.
Database

Entrez Gene: 8431 Human ;

SwissProt: Q15466 Human ;

OMIM: 601665 Human

Documentation
SDS (251 KB)

COA (191 KB)

User Guide for Antibodies (1077 KB)

NR0B2 Antibody Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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NR0B2 Antibody
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HY-P83732
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