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  5. NMDAR1 Antibody (YA265)

NMDAR1 Antibody (YA265)

Cat. No.: HY-P80247
COA
SDS
User Guide for Antibodies Technical Support

NMDAR1 Antibody (YA265) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NMDAR1.

For research use only. We do not sell to patients.

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50 μL In-stock
100 μL In-stock
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

NMDAR1 Antibody (YA265) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NMDAR1.
Background

NMDAR1 is a component of N-methyl-D-aspartate (NMDA) receptors (NMDARs), which function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg2+. NMDARs participate in synaptic plasticity for learning and memory formation by contributing to long-term potentiation (LTP). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+. NMDARs mediate simultaneously potassium efflux and the influx of calcium and sodium (by similar). Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.
Tag

Free
Gene ID
SwissProt ID
Molecular Weight

Predicted band size: 105 kDa; Observed band size: 120 kDa
Purity

Protein A affinity purified.
Subcellular Location

Cell membrane, postsynaptic cell membrane, postsynaptic density.
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Neuroscience
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1:500-1:2,000 ;ICC/IF: 1:100-1:500 ;IHC-P: 1:50-1:800 ;FC: 1:50-1:100
Application

WB, ICC/IF, IHC-P, FC
Appearance

Liquid
Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

Synthetic peptide corresponding to Human NMDAR1.AA range:870-910.
Database

Entrez Gene: 2902 Human ; 14810 Mouse ; 24408 Rat

SwissProt: Q05586 Human ; P35438 Mouse ; P35439 Rat

OMIM: 614254 Human

Documentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

NMDAR1 Antibody (YA265) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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NMDAR1 Antibody (YA265)
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