NG2 Antibody (YA3221)

NG2 Antibody (YA3221) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3221), targeting NG2, with a predicted molecular weight of 251 kDa (observed band size: 251 kDa). NG2 Antibody (YA3221) can be used for WB, IHC-P, FC experiment in human background.

NG2 is a proteoglycan that plays a role in cell proliferation and migration, stimulating endothelial cell motility during microvascular morphogenesis. It may also inhibit neurite outgrowth and growth cone collapse during axon regeneration. As a cell surface receptor for collagen alpha 2(VI), NG2 may confer cells the ability to migrate on that substrate. Through its extracellular N-terminus, NG2 binds growth factors and extracellular matrix proteases, modulating their activity. It may regulate MPP16-dependent degradation and invasion of type I collagen, participating in melanoma cell invasion properties. Additionally, NG2 can modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. It also functions as a signal-transducing protein by binding scaffolding and signaling proteins through its cytoplasmic C-terminus. NG2 may promote retraction fiber formation and cell polarization through Rho GTPase activation. Furthermore, it stimulates alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1, and BCAR1. NG2 may also activate FAK and ERK1/ERK2 signaling cascades.

Q6UVK1

Predicted band size: 251 kDa; Observed band size: 251 kDa

Affinity Chromatography

Non-conjugated

Unmodified

Neuroscience

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1/500-1/1000;IHC: 1/50-1/100;FC: 1/50-1/100

WB, IHC-P, FC

Liquid

Supplied in rabbit IgG in 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human NG2