STK3/MST-2 Antibody (YA282)

Cat. No.: HY-P80230: Data Sheet COA
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STK3/MST-2 Antibody (YA282) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STK3/MST-2.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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STK3/MST-2 Antibody (YA282) Featured Recommendations:

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

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Description	STK3/MST-2 Antibody (YA282) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STK3/MST-2.
Background	MST2 protein, a stress-activated, pro-apoptotic kinase, contributes to various cellular processes, serving as a key component in the Hippo signaling pathway that plays a central role in organ size control and tumor suppression. Upon caspase-cleavage, MST2 enters the nucleus, inducing chromatin condensation and internucleosomal DNA fragmentation, promoting apoptosis. In the Hippo pathway, MST2, along with its counterpart STK4/MST1 and the regulatory protein SAV1, forms a kinase cascade crucial for phosphorylating and activating LATS1/2-MOB1 complex. This cascade further phosphorylates and inactivates the YAP1 oncoprotein and WWTR1/TAZ, regulating genes essential for cell proliferation, death, and migration. MST2 and MST1 are vital for repressing hepatocyte proliferation, preventing activation of facultative adult liver stem cells, and inhibiting tumor formation. Beyond the Hippo pathway, MST2 phosphorylates NKX2-1, NEK2, CROCC, CEP250, MOBKL1A, MOBKL1B, and RASSF2, exerting influence on centrosome disjunction, RAF1 activation, ESR1 transcriptional activity, and STK38 activation. MST2, working in conjunction with SAV1, positively regulates RAF1 activation by suppressing inhibitory phosphorylation on 'Ser-259' and collaborates with MOBKL1B to activate STK38.
Tag	Free
Gene ID	6788 [NCBI]
SwissProt ID	Q13188
Synonyms	MST-2; STK3; KRS1; MST2
Molecular Weight	Predicted band size: 56 kDa; Observed band size: 56 kDa
Purity	Protein A affinity purified.
Subcellular Location	Nucleus, Cytoplasm.
Conjugation	Non-conjugated
Modification	Unmodified
RRID	AB_3102363
Research Field	Cell Biology
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human, Mouse
Dilution Ratio	WB: 1:1,000-1:5,000; IHC-P: 1:50-1:200; IP: Use at an assay dependent concentration.
Application	WB, IHC-P, IP
Appearance	Liquid
Formulation	Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	Synthetic peptide within N-terminal human Mst2.
Database	Entrez Gene: 6788 Human ; 58231 Mouse ; SwissProt: Q13188 Human ; Q9JI11 Mouse ; OMIM: 605030 Human
Documentation	Select Batch: Data Sheet (236 KB) SDS (251 KB) COA (205 KB) User Guide for Antibodies (1077 KB)

STK3/MST-2 Antibody (YA282) Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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STK3/MST-2 Antibody (YA282)

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