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  4. Monoclonal Antibodies Recombinant Antibodies
  5. MOV10 Antibody (YA1669)

MOV10 Antibody (YA1669)

Cat. No.: HY-P81924
COA
SDS
User Guide for Antibodies Technical Support

MOV10 Antibody (YA1669) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MOV10.

For research use only. We do not sell to patients.

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10 μL In-stock
50 μL In-stock
100 μL In-stock
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

MOV10 Antibody (YA1669) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MOV10.
Background

MOV10 is a 5' to 3' RNA helicase involved in diverse cellular processes, including mRNA metabolism, translation regulation, modulation of viral infectivity, retrotransposition inhibition, and synaptic transmission. It plays a pivotal role in innate antiviral immunity by promoting type I interferon production, specifically utilizing IKKepsilon/IKBKE to activate IRF3. MOV10 blocks HIV-1 replication post-entry and counteracts HIV-1 Vif-mediated APOBEC3G degradation via helicase activity. It also inhibits hepatitis B virus replication by binding HBV RNA. The protein contributes to UPF1-mediated mRNA decay and is essential for miRNA-driven gene silencing, including translational repression and RISC-mediated mRNA cleavage. Collaborating with FMR1, it fine-tunes AGO2-dependent miRNA repression and, alongside TUT4/TUT7, restricts LINE-1 retrotransposition. During brain development, MOV10 suppresses retroelements in the nucleus while regulating cytoskeletal mRNAs for neurite outgrowth (by similar). It may function as an mRNP clearance factor and is required for hepatitis delta virus RNA-directed transcription/replication.
Gene ID
SwissProt ID
Synonyms
gb110; MOV 10
Molecular Weight

Predicted band size: 114 kDa; Observed band size: 114 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Epigenetics and Nuclear Signaling
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000;IHC: 1/50-1/100
Application

WB, IHC-P
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthesized peptide derived from human Mov10
Database

Entrez Gene: 4343 Human ; 17454 Mouse ; 310756 Rat

SwissProt: Q9HCE1 Human ; P23249 Mouse ;

OMIM: 610742 Human

Documentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

MOV10 Antibody (YA1669) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MOV10 Antibody (YA1669)
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HY-P81924
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