2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. MMP3 Antibody (YA286)

MMP3 Antibody (YA286) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP3.

For research use only. We do not sell to patients.

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50 μL In-stock
100 μL In-stock
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

MMP3 Antibody (YA286) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP3.
Background

MMP3 is a metalloproteinase with broad substrate specificity, capable of degrading fibronectin, laminin, gelatins of types I, III, IV, and V, as well as collagens III, IV, X, and IX, and cartilage proteoglycans. It activates various molecules, including growth factors, plasminogen, or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. MMP3 also functions intracellularly—for example, in dopaminergic neurons, it is activated by the serine protease HTRA2 under stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage. Additionally, it contributes to immune responses and exhibits antiviral activity against viruses like vesicular stomatitis virus, influenza A virus (H1N1), and human herpes virus 1. Mechanistically, upon viral infection, it translocates from the cytoplasm to the nucleus to modulate NF-kappa-B activities.
Tag

Free
Gene ID
SwissProt ID
Molecular Weight

Predicted band size: 54 kDa; Observed band size: 50 kDa
Purity

Protein A affinity purified.
Subcellular Location

extracellular matrix.
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Cardiovascular

Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1:500-1:2000; IHC-P: 1:50-1:200
Application

WB, IHC-P
Appearance

Liquid
Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

Synthetic peptide within C-terminal human MMP3.
Database

Entrez Gene: 4314 Human ; 17392 Mouse ;

SwissProt: P08254 Human ; P28862 Mouse ; P03957 Rat

OMIM: 614466 Human

Documentation
SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

MMP3 Antibody (YA286) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MMP3 Antibody (YA286)
Cat. No.:
HY-P80424
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